Pyridine → Benzyl 2-(3-fluoro-4-(2-hydroxy-3-(methoxycarbonyl)phenylcarbamyl)phenyl)pyrrolidine-1-carboxylate

HRID 105156Notes

Reaction equation

HRID 105156 reaction equation
[Cl:19][C:20](=[O:21])[c:22]1[c:23]([F:43])[cH:24][c:25]([CH:28]2[N:29]([C:33](=[O:34])[O:35][CH2:36][c:37]3[cH:38][cH:39][cH:40][cH:41][cH:42]3)[CH2:30][CH2:31][CH2:32]2)[cH:26][cH:27]1.[Cl:44][CH2:45][Cl:46].[NH2:1][c:2]1[c:3]([OH:12])[c:4]([C:5](=[O:6])[O:7][CH3:8])[cH:9][cH:10][cH:11]1.[cH:13]1[cH:14][cH:15][n:16][cH:17][cH:18]1>>[NH:1]([c:2]1[c:3]([OH:12])[c:4]([C:5](=[O:6])[O:7][CH3:8])[cH:9][cH:10][cH:11]1)[C:20](=[O:21])[c:22]1[c:23]([F:43])[cH:24][c:25]([CH:28]2[N:29]([C:33](=[O:34])[O:35][CH2:36][c:37]3[cH:38][cH:39][cH:40][cH:41][cH:42]3)[CH2:30][CH2:31][CH2:32]2)[cH:26][cH:27]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 6344DichloromethaneHCID 12782444Methyl 3-amino-2-hydroxybenzoateHCID 86633086Benzyl 2-(4-(chlorocarbonyl)-3-fluorophenyl)pyrrolidine-1-carboxylate

Product 1

HCID 66620560Benzyl 2-(3-fluoro-4-(2-hydroxy-3-(methoxycarbonyl)phenylcarbamyl)phenyl)pyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-90d479ece0ba491ca0919cb2783002a9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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