Dichloromethane → 5-Amino-7'-bromo-5'-fluorospiro[2,6-dihydro-1,4-oxazine-3,9'-xanthene]-2'-ol

HRID 105164Notes

Reaction equation

HRID 105164 reaction equation
[B:25]([Br:26])([Br:27])[Br:28].[Br:1][c:2]1[cH:3][c:4]2[c:5]([c:6]([F:8])[cH:7]1)[O:9][c:10]1[cH:11][cH:12][c:13]([O:23][CH3:24])[cH:14][c:15]1[C:16]21[CH2:17][O:18][CH2:19][C:20]([NH2:22])=[N:21]1.[Cl:29][CH2:30][Cl:31]>>[Br:1][c:2]1[cH:3][c:4]2[c:5]([c:6]([F:8])[cH:7]1)[O:9][c:10]1[cH:11][cH:12][c:13]([OH:23])[cH:14][c:15]1[C:16]21[CH2:17][O:18][CH2:19][C:20]([NH2:22])=[N:21]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 25134Boron tribromideHCID 674392762'-Bromo-4'-fluoro-7'-methoxyspiro[2,6-dihydro-1,4-oxazine-5,9'-xanthene]-3-amine

Product 1

HCID 674376595-Amino-7'-bromo-5'-fluorospiro[2,6-dihydro-1,4-oxazine-3,9'-xanthene]-2'-ol

Sources & evidence

ORD record
ord-551a18b727654684a7603754be911568
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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