3-fluoroazetidine Hydrochloride → HCID 89633542, compound

HRID 1051860Notes

Reaction equation

HRID 1051860 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][C:3]=1[O:11][CH2:12][C:13]([F:16])([F:15])[F:14].Cl.[F:18][CH:19]1[CH2:22][NH:21][CH2:20]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:21]2[CH2:22][CH:19]([F:18])[CH2:20]2)=[O:8])=[CH:4][C:3]=1[O:11][CH2:12][C:13]([F:16])([F:15])[F:14]

Participants

3

Reactant 2

HCID 101250543-fluoroazetidine HydrochlorideHCID 59581703HCID 59581703, compound

Product 1

HCID 89633542HCID 89633542, compound

Procedure

Starting with 4-bromo-3-(2,2,2-trifluoroethoxy)benzoic acid and 3-fluoroazetidine hydrochloride, Int06.04 was prepared analogously to the procedure for the preparation of Int02.06.

Workup

  1. customwas prepared analogously to the procedure for the preparation of Int02.06

Sources & evidence

ORD record
ord-3e2027ed0de2420e80f853f0925dddad
Source dataset
uspto-grants-2016_07
Patent number
US09388177B2

Reaction notes

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