3-Hydroxyazetidine hydrochloride → HCID 71062062, compound

HRID 1051861Notes

Reaction equation

HRID 1051861 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][C:3]=1[O:11][CH2:12][C:13]([F:16])([F:15])[F:14].Cl.[NH:18]1[CH2:21][CH:20]([OH:22])[CH2:19]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:18]2[CH2:21][CH:20]([OH:22])[CH2:19]2)=[O:8])=[CH:4][C:3]=1[O:11][CH2:12][C:13]([F:16])([F:15])[F:14]

Participants

3

Reactant 2

HCID 27592903-Hydroxyazetidine hydrochlorideHCID 59581703HCID 59581703, compound

Product 1

HCID 71062062HCID 71062062, compound

Procedure

Starting with 4-bromo-3-(2,2,2-trifluoroethoxy)benzoic acid and azetidin-3-ol hydrochloride, Int06.05 was prepared analogously to the procedure for the preparation of Int02.03.

Workup

  1. customwas prepared analogously to the procedure for the preparation of Int02.03

Sources & evidence

ORD record
ord-d1a20dc998e1432bab2eaaf2c82ee8dc
Source dataset
uspto-grants-2016_07
Patent number
US09388177B2

Reaction notes

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