1,2-Dichloroethane → 8-Oxa-3-azabicyclo[3.2.1]octan-3-yl(4-bromothiazol-2-yl)methanone

Temperature

0 °C

To a solution of 4-bromothiazole-2-carboxylic acid (prepared according to the procedure given in WO 2008/57336, 1.00 g, 4.82 mmol) in DMF (15 ml) was added HOST (0.88 g, 5.78 mmol) at room temperature, followed by the addition of (1R,5S)-8-oxa-3-azabicyclo[3.2.1]octane (prepared according to the procedure given in WO 2004/31186, 0.60 gm, 5.30 mmol). The reaction mixture was cooled to 0° C. and to this were added EDC (1.38 g, 7.23 mmol) and triethylamine (1.46 g, 2.02 ml, 14.46 mmol). The reaction mixture was stirred at room temperature for 15 hr and the progress of reaction was monitored by TLC. The reaction mixture was concentrated under reduced pressure. The residue so obtained was taken in ethyl acetate (150 ml) and washed with saturated sodium bicarbonate solution (1×40 ml), brine (1×20 ml) and organic layers separated were dried over anhydrous sodium sulphate, filtered and concentrated under reduced pressure to get a crude product. The crude product was purified by column chromatography over silica gel (100-200 mesh) using 25% ethyl acetate in hexanes as an eluent to obtain the title compound (0.45 g, 30.8%). MS: m/z 304 (M+1).

1. additionwas added HOST (0.88 g, 5.78 mmol) at room temperature
2. customprepared
3. customthe progress of reaction
4. concentrationThe reaction mixture was concentrated under reduced pressure
5. customThe residue so obtained
6. washwashed with saturated sodium bicarbonate solution (1×40 ml), brine (1×20 ml) and organic layers
7. customseparated
8. dry with materialwere dried over anhydrous sodium sulphate
9. filtrationfiltered
10. concentrationconcentrated under reduced pressure
11. customto get a crude product
12. customThe crude product was purified by column chromatography over silica gel (100-200 mesh)

ORD record

ord-b715e27dff48436798a3c1f55ef241d8

Source dataset

uspto-grants-2016_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09388196B2