1,2-Dichloroethane → HCID 89813286, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-(4-chlorophenyl)thiazole-2-carboxylic acid (prepared according to the procedure given in US 2007/32531, 1.00 g, 4.17 mmol) in DMF (10 ml) was added HOST (0.96 g, 6.26 mmol) at room temperature, followed by the addition of piperidine (0.42 g, 5.01 mmol). The reaction mixture was cooled to 0° C. and to this were added EDC (1.20 g, 6.26 mmol) and triethylamine (2.11 g, 2.91 ml, 20.86 mmol). The reaction mixture was stirred at room temperature for 15 hr and the progress of reaction was monitored by TLC. The reaction mixture was concentrated under reduced pressure. The residue so obtained was taken in ethyl acetate (50 ml) and washed with saturated sodium bicarbonate solution (1×40 ml), brine (1×20 ml) and organic layers separated were dried over anhydrous sodium sulphate, filtered and concentrated under reduced pressure to get a crude product. The crude product was purified by column chromatography over silica gel (100-200 mesh) using 40% ethyl acetate in hexanes as an eluent to obtain the title compound (0.41 g, 32.4%). MS: m/z 308 (M+1).

Provenance & Evidence