HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Amino-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | Methyl 2-amino-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylate | HCID 90303268 | — |
| Solvent | Methanol tetrahydrofuran water | HCID 21892291 | — |
| Product | 2-Amino-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylic acid | HCID 83880316 | — |
Reaction Steps
A mixture of methyl 2-amino-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylate (52 mg, 0.24 mmol) and LiOH.H2O (12 mg, 0.29 mmol) in THF/MeOH/H2O (2.5 mL, 3:1:1) was stirred at RT for 2 h. The mixture was neutralized with aq. HCl and conc. in vacuo. The crude yellow solid was used without any further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09388197B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-f718d837fd8c4d0a8d844a8f41f7e570 |
| Source note | uspto-grants-2016_07 |