HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium hydroxide, monohydrate → 2-Methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | Methyl 2-methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylate | HCID 90303556 | — |
| Solvent | Methanol tetrahydrofuran water | HCID 21892291 | — |
| Product | 2-Methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylic acid | HCID 82276903 | — |
Reaction Steps
A mixture of methyl 2-methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylate (59 mg, 0.28 mmol) and LiOH.H2O (14 mg, 0.33 mmol) in THF/MeOH/H2O (2.5 mL, 3:1:1) was stirred at RT for 2 h. The mixture was acidified to pH=3 and extracted with EtOAc. The comb. org. layers were dried over MgSO4, and conc. in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09388197B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-05c36b194d0f492d9a17c4ac3aa5227e |
| Source note | uspto-grants-2016_07 |