HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1051937Generated: November 2, 2026
Sodium Acetate → 3,5-Dichloro-2-cyanobenzyl acetate
https://huagongshe.com/reaction/1051937
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 2-(Bromomethyl)-4,6-dichlorobenzonitrile | HCID 89704997 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 3,5-Dichloro-2-cyanobenzyl acetate | HCID 89704760 | — |
Reaction Steps
To a soln. of 2-(bromomethyl)-4,6-dichlorobenzonitrile (15.1 mmol) in 30 mL AcOH was added NaOAc (75.7 mmol). The suspension was heated to 100° C. for 2 h. The solvent was evaporated off and the residue partitioned between DCM and water. The org. phase was washed with water, dried over MgSO4 and conc. in vacuo. Purification with CC (5-70% EtOAc/Hept) gives the desired compound as white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09388197B2 |
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| Source dataset | uspto-grants-2016_07 |
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| ORD ID | ord-49248ed03b8441708d7f4efcba372914 |
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| Source note | uspto-grants-2016_07 |
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