Methyl iodide → 2,4-Dichloro-6-methoxybenzaldehyde

https://huagongshe.com/reaction/1051939

Participants

Role	Name	HCID	Charge
Reactant	Methyl iodide	HCID 6328	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	2,4-Dichloro-6-hydroxybenzaldehyde	HCID 528390	—
Solvent	Dimethylformamide	HCID 6228	—
Solvent	Ethyl Acetate	HCID 8857	—
Product	2,4-Dichloro-6-methoxybenzaldehyde	HCID 12802880	—

Reaction Conditions

Temperature	50 °C

Reaction Steps

To a soln. of 4,6-dichlorosalicylaldehyde (2.69 mmol) in 5 mL DMF was added K2CO3 (5.39 mmol) followed by iodomethane (2.96 mmol). The reaction mixture was heated to 50° C. for 3.5 h. At RT, the mixture was diluted with EtOAc and washed 3 times with water and then with brine. The comb. org. layers were dried over MgSO4 and conc. in vacuo to give the desired product as beige solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09388197B2
Source dataset	uspto-grants-2016_07
ORD ID	ord-7e13d4c2078f4da78382de93e06ea9d8
Source note	uspto-grants-2016_07