Hydrochloric Acid → 2-((3,5-Dichloro-2-cyanobenzyl)oxy)ethyl acetate

Participants

Reaction Steps

To a soln. of 2-(bromomethyl)-4,6-dichlorobenzonitrile (1.3 mmol) (A.2.2.1.) and 2-hydroxyethyl acetate (1.43 mmol) in 7 mL THF was added NaH (1.95 mmol, 60% suspension in oil). The reaction mixture was stirred at RT overnight and then poured into a 1M HCl soln. The mixture was extracted twice with EtOAc. The comb. org. layers were washed with brine, dried over MgSO4 and conc. in vacuo. Purification with CC (0-25% EtOAc/Hept) gives the desired compound as orange oil.

Provenance & Evidence