Cesium carbonate → HCID 90303551, compound

Participants

Reaction Steps

A soln. of 3-(4-chlorothiazol-5-yl)-3-((tetrahydro-2H-pyran-2-yl)oxy)propan-1-ol (520 mg, 1.87 mmol) in MePh (10 mL) was added to a Ar-filled vial charged with Pd(OAc)2 (63 mg, 0.28 mmol), 2-(di-tert-butylphosphino)-1,1′-binaphthyl (140 mg, 0.35 mmol) and Cs2CO3 (915 mg, 2.81 mmol). The vial was sealed and placed in a preheated oilbath (100° C.) overnight. Subsequently, the mixture was diluted with DCM, filtrated over Celite, and conc. in vacuo. Purification by means of CC (20-80% EtOAc/Hept) provided the product as a yellow oil as an isomeric mixture.

Provenance & Evidence