Hydrochloride methanol → HCID 178418692, compound

HRID 10520Notes

Reaction equation

HRID 10520 reaction equation
C(OC([NH:8][C@H:9]1[CH2:14][CH2:13][C@@H:12]([NH:15][C:16]2[CH:25]=[CH:24][CH:23]=[C:22]3[C:17]=2[CH:18]=[CH:19][N:20]=[CH:21]3)[CH2:11][CH2:10]1)=O)(C)(C)C.[ClH:26].CO>>[ClH:26].[CH:21]1[C:22]2[C:17](=[C:16]([NH:15][C@H:12]3[CH2:11][CH2:10][C@@H:9]([NH2:8])[CH2:14][CH2:13]3)[CH:25]=[CH:24][CH:23]=2)[CH:18]=[CH:19][N:20]=1

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 178418965HCID 178418965, compound

Product 1

HCID 178418692HCID 178418692, compound

Procedure

According to the method of Example 1, Step C, deprotection was performed (room temperature, 31 hours) by using Intermediate 39 (214 mg) and 10% hydrogen chloride/methanol solution (5 ml). The solvent was evaporated under reduced pressure, and the residue was added with methanol (1 ml) and diethyl ether (3 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (215 mg) as light yellow powdery solid.

Workup

  1. custom(room temperature, 31 hours)
  2. customThe solvent was evaporated under reduced pressure
  3. additionthe residue was added with methanol (1 ml) and diethyl ether (3 ml)
  4. customThe deposited precipitates
  5. filtrationwere collected by filtration
  6. washwashed with diethyl ether

Sources & evidence

ORD record
ord-8889760d8b024e68bc4a6d002cdc2fe4
Source dataset
uspto-grants-2006_08
Patent number
US07094789B2

Reaction notes

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