m-Toluidine → HCID 89789900, compound

HRID 1052025Notes

Reaction equation

HRID 1052025 reaction equation
[CH3:1][S:2][C:3]1[N:4]=[CH:5][C:6]2[CH2:12][N:11]([C:13]3[N:18]=[C:17]([C:19]([OH:21])=O)[CH:16]=[CH:15][CH:14]=3)[CH2:10][CH2:9][C:7]=2[N:8]=1.[NH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([CH3:29])[CH:24]=1>>[CH3:29][C:25]1[CH:24]=[C:23]([NH:22][C:19]([C:17]2[CH:16]=[CH:15][CH:14]=[C:13]([N:11]3[CH2:10][CH2:9][C:7]4[N:8]=[C:3]([S:2][CH3:1])[N:4]=[CH:5][C:6]=4[CH2:12]3)[N:18]=2)=[O:21])[CH:28]=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 7934m-ToluidineHCID 866958356-[2-(Methylthio)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-6-yl]pyridine-2-carboxylic acid

Product 1

HCID 89789900HCID 89789900, compound

Procedure

In a manner similar to that described in Example 108, a mixture of 6-[2-(methylthio)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-6-yl]pyridine-2-carboxylic acid and m-toluidine were converted to the title compound.

Sources & evidence

ORD record
ord-1eaf113a245f472f908f9955fec140ba
Source dataset
uspto-grants-2016_07
Patent number
US09388176B2

Reaction notes

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