Aniline → 2-Bromo-N-phenyl-isonicotinamide

HRID 1052026Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][N:10]=1)[C:5]([OH:7])=O.[NH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][N:10]=1)[C:5]([NH:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:7]

Participants

Reactant 2

HCID 6115Aniline

HCID 2227012-Bromoisonicotinic acid

Product 1

HCID 866958402-Bromo-N-phenyl-isonicotinamide

Procedure

In a manner similar to that described in Preparation 17, 2-bromoisonicotinic acid and aniline were converted to the title compound

Sources & evidence

ORD record: ord-5c4c5c377ae64e94b2681d8caaa8661e
Source dataset: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09388176B2

Reaction notes

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