m-Toluidine → 2-Bromo-N-m-tolyl-isonicotinamide

HRID 1052027Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][N:10]=1)[C:5]([OH:7])=O.[NH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH3:18])[CH:13]=1>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][N:10]=1)[C:5]([NH:11][C:12]1[CH:13]=[C:14]([CH3:18])[CH:15]=[CH:16][CH:17]=1)=[O:7]

Participants

Reactant 2

HCID 7934m-Toluidine

HCID 2227012-Bromoisonicotinic acid

Product 1

HCID 866958412-Bromo-N-m-tolyl-isonicotinamide

Procedure

In a manner similar to that described in Preparation 17, 2-bromoisonicotinic acid and m-toluidine were converted to the title compound

Sources & evidence

ORD record: ord-8bb6a3145b784458919c6caa0b9591d8
Source dataset: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09388176B2

Reaction notes

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