2-(Methylthio)-5,6,7,8-tetrahydropyrido[4,3-D]pyrimidine → 2-[2-(methylthio)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]-N-[3-(trifluoromethyl)phenyl]isonicotinamide

HRID 1052033Notes

Reaction equation

HRID 1052033 reaction equation
[CH3:1][S:2][C:3]1[N:4]=[CH:5][C:6]2[CH2:12][NH:11][CH2:10][CH2:9][C:7]=2[N:8]=1.Br[C:14]1[CH:15]=[C:16]([CH:30]=[CH:31][N:32]=1)[C:17]([NH:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:28])[F:27])[CH:21]=1)=[O:18]>>[CH3:1][S:2][C:3]1[N:4]=[CH:5][C:6]2[CH2:12][N:11]([C:14]3[CH:15]=[C:16]([CH:30]=[CH:31][N:32]=3)[C:17]([NH:19][C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:27])([F:28])[F:29])[CH:21]=3)=[O:18])[CH2:10][CH2:9][C:7]=2[N:8]=1

Participants

3

Reactant 2

HCID 552636702-(Methylthio)-5,6,7,8-tetrahydropyrido[4,3-D]pyrimidineHCID 866958424-Pyridinecarboxamide, 2-bromo-N-[3-(trifluoromethyl)phenyl]-

Product 1

HCID 866958472-[2-(methylthio)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]-N-[3-(trifluoromethyl)phenyl]isonicotinamide

Procedure

In a manner similar to that described for Example 138, 2-(methylsulfanyl)-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidine and 2-bromo-N-(3-trifluoromethyl-phenyl)-isonicotinamide were converted to the title compound.

Sources & evidence

ORD record
ord-c521cb20038445fea708abbd2c1bd1f5
Source dataset
uspto-grants-2016_07
Patent number
US09388176B2

Reaction notes

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