3-(Trifluoromethyl)aniline → HCID 17197565, compound

HRID 1052053Notes

Reaction equation

HRID 1052053 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[CH3:11])[C:5]([OH:7])=O.[F:12][C:13]([F:22])([F:21])[C:14]1[CH:15]=[C:16]([CH:18]=[CH:19][CH:20]=1)[NH2:17]>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[CH3:11])[C:5]([NH:17][C:16]1[CH:18]=[CH:19][CH:20]=[C:14]([C:13]([F:12])([F:21])[F:22])[CH:15]=1)=[O:7]

Participants

3

Reactant 2

HCID 73753-(Trifluoromethyl)anilineHCID 821303-Bromo-4-methylbenzoic acid

Product 1

HCID 17197565HCID 17197565, compoundYield 62%

Procedure

In a manner similar to that described in Preparation 41, 3-bromo-4-methylbenzoic acid (400 mg) and 3-(trifluoromethyl)aniline were converted to the title compound (410 mg, 62%)

Sources & evidence

ORD record
ord-d752024d0fa849bf86414e5470ba34c5
Source dataset
uspto-grants-2016_07
Patent number
US09388176B2

Reaction notes

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