HCID 977755, compound → HCID 86695863, compound

HRID 1052063Notes

Reaction equation

HRID 1052063 reaction equation
[CH3:1][S:2][C:3]1[N:4]=[CH:5][C:6]2[CH2:12][NH:11][CH2:10][CH2:9][C:7]=2[N:8]=1.Br[C:14]1[CH:15]=[N:16][CH:17]=[C:18]([CH:32]=1)[C:19]([NH:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([F:31])([F:30])[F:29])[CH:23]=1)=[O:20]>>[CH3:1][S:2][C:3]1[N:4]=[CH:5][C:6]2[CH2:12][N:11]([C:14]3[CH:15]=[N:16][CH:17]=[C:18]([CH:32]=3)[C:19]([NH:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([F:31])([F:29])[F:30])[CH:23]=3)=[O:20])[CH2:10][CH2:9][C:7]=2[N:8]=1

Participants

3

Reactant 2

HCID 977755HCID 977755, compoundHCID 552636702-(Methylthio)-5,6,7,8-tetrahydropyrido[4,3-D]pyrimidine

Product 1

HCID 86695863HCID 86695863, compound

Procedure

In a manner similar to that described for Example 138, 2-(methylsulfanyl)-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidine and 5-bromo-N-(3-(trifluoromethyl)phenyl)nicotinamide were converted to the title compound.

Sources & evidence

ORD record
ord-8a5f7ad5e77c4d31a4f4e119298f2335
Source dataset
uspto-grants-2016_07
Patent number
US09388176B2

Reaction notes

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