Ammonia → 3'-Azido-2',3'-dideoxy-5-fluorouridine

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Reaction Steps

3′-Azido-5′-benzoyl-2′,3′-dideoxy-5-fluorouridine prepared in step B above (2.5 g) was suspended in methanol saturated with ammonia (200 mL) and stirred using a magnetic stirrer at room temperature for 12 hours. Subsequently, the methanol was removed using a vacuum evaporator, and the solid residue was subjected to column chromatography on silica gel with chloroform-methanol (40:1, v/v) as the mobile phase. Yield of AddFU: 1.64 g, 91%.

Provenance & Evidence