Hydrochloride methanol → HCID 178418802, compound

HRID 10522Notes

Reaction equation

HRID 10522 reaction equation
C(OC([NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([NH:15][C:16]2[CH:25]=[CH:24][CH:23]=[C:22]3[C:17]=2[CH:18]=[CH:19][N:20]=[CH:21]3)[CH2:11][CH2:10]1)=O)(C)(C)C.[ClH:26].CO>>[ClH:26].[CH:21]1[C:22]2[C:17](=[C:16]([NH:15][C@H:12]3[CH2:11][CH2:10][C@H:9]([NH2:8])[CH2:14][CH2:13]3)[CH:25]=[CH:24][CH:23]=2)[CH:18]=[CH:19][N:20]=1

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 178418804HCID 178418804, compound

Product 1

HCID 178418802HCID 178418802, compound

Procedure

According to the method of Example 1, Step C, deprotection was performed (50° C., 1 hour) by using Intermediate 41 (69 mg) and 10% hydrogen chloride/methanol solution (4 ml). The solvent was evaporated under reduced pressure, and the residue was added with methanol (0.5 ml) and diethyl ether (2 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (58.7 mg) as light yellow powdery solid.

Workup

  1. custom(50° C., 1 hour)
  2. customThe solvent was evaporated under reduced pressure
  3. additionthe residue was added with methanol (0.5 ml) and diethyl ether (2 ml)
  4. customThe deposited precipitates
  5. filtrationwere collected by filtration
  6. washwashed with diethyl ether

Sources & evidence

ORD record
ord-b3463dd1e45d4ff9a4d87ab1ddd0da87
Source dataset
uspto-grants-2006_08
Patent number
US07094789B2

Reaction notes

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