HCID 73055080, compound → HCID 73055362, compound

Participants

Reaction Steps

To a stirred solution of 2-[2-(3,5-dimethoxyphenyl)ethyl]-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine (from Example 23, 10 mg, 26.4 μmol) in methanol (1 mL), Pd/C (10% w/w, 3.2 mg, 3.0 μmol) was added. The reaction mixture was then stirred under the atmosphere of H2 at ambient temperature. After 3 hours, the palladium catalyst was filtered and the crude mixture was purified on RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.05% TFA, at flow rate of 30 mL/min) to give the desired product (3.0 mg, 30%) as its TFA salt. LCMS calculated for C22H29N4O2 (M+H)+: m/z=381.2. Found: 381.3.

Provenance & Evidence