(3-Chloro-4-(dimethylcarbamoyl)phenyl)boronic acid → 2-Chloro-4-(2-(3,5-dimethoxyphenethyl)-5H-pyrrolo[2,3-b]pyrazin-6-yl)-N,N-dimethylbenzamide

Participants

Role	Name	HCID	Charge
Reactant	(3-Chloro-4-(dimethylcarbamoyl)phenyl)boronic acid	HCID 44119415	—
Reactant	6-Bromo-2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3-b]pyrazine	HCID 89962437	—
Product	2-Chloro-4-(2-(3,5-dimethoxyphenethyl)-5H-pyrrolo[2,3-b]pyrazin-6-yl)-N,N-dimethylbenzamide	HCID 73057464	—

Reaction Steps

The compound was prepared by using procedures analogous to those described for the synthesis of Example 53, Step 2 starting from 6-bromo-2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3-b]pyrazine and 3-chloro-4-(dimethylcarbamoyl)phenylboronic acid (from Combi-Blocks). LCMS calculated for C25H26ClN4O3 (M+H)+: m/z=465.2. Found 465.1.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09388185B2
Source dataset	uspto-grants-2016_07
ORD ID	ord-048d2f87c4c24dcab3dc1c933d99268b
Source note	uspto-grants-2016_07