(4-Cyano-3-fluorophenyl)boronic acid → HCID 73058042, compound

HRID 1052285Notes

Reaction equation

HRID 1052285 reaction equation
Br[C:2]1[NH:22][C:5]2=[N:6][CH:7]=[C:8]([CH2:10][CH2:11][C:12]3[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[C:14]([O:20][CH3:21])[CH:13]=3)[N:9]=[C:4]2[CH:3]=1.[C:23]([C:25]1[CH:30]=[CH:29][C:28](B(O)O)=[CH:27][C:26]=1[F:34])#[N:24]>>[CH3:21][O:20][C:14]1[CH:13]=[C:12]([CH:17]=[C:16]([O:18][CH3:19])[CH:15]=1)[CH2:11][CH2:10][C:8]1[N:9]=[C:4]2[CH:3]=[C:2]([C:29]3[CH:28]=[CH:27][C:26]([F:34])=[C:25]([CH:30]=3)[C:23]#[N:24])[NH:22][C:5]2=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 2783130(4-Cyano-3-fluorophenyl)boronic acidHCID 899624376-Bromo-2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3-b]pyrazine

Product 1

HCID 73058042HCID 73058042, compound

Procedure

The compound was prepared by using procedures analogous to those described for the synthesis of Example 53, Step 2 starting from 6-bromo-2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3-b]pyrazine and (4-cyano-3-fluorophenyl)boronic acid (from Aldrich). LCMS calculated for C23H20FN4O2(M+H)+: m/z=403.2. Found 403.2.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-d6f3a61e66cd4895b8f7b6b9af531682
Source dataset
uspto-grants-2016_07
Patent number
US09388185B2

Reaction notes

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