1105665-06-2 → HCID 73058327, compound

HRID 1052292Notes

Reaction equation

HRID 1052292 reaction equation
Br[C:2]1[NH:22][C:5]2=[N:6][CH:7]=[C:8]([CH2:10][CH2:11][C:12]3[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[C:14]([O:20][CH3:21])[CH:13]=3)[N:9]=[C:4]2[CH:3]=1.[CH3:23][N:24]1[CH2:29][CH2:28][N:27]([C:30]2[CH:37]=[CH:36][C:35](B3OC(C)(C)C(C)(C)O3)=[CH:34][C:31]=2[C:32]#[N:33])[CH2:26][CH2:25]1>>[CH3:21][O:20][C:14]1[CH:13]=[C:12]([CH:17]=[C:16]([O:18][CH3:19])[CH:15]=1)[CH2:11][CH2:10][C:8]1[N:9]=[C:4]2[CH:3]=[C:2]([C:35]3[CH:36]=[CH:37][C:30]([N:27]4[CH2:28][CH2:29][N:24]([CH3:23])[CH2:25][CH2:26]4)=[C:31]([CH:34]=3)[C:32]#[N:33])[NH:22][C:5]2=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 595586081105665-06-2HCID 899624376-Bromo-2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3-b]pyrazine

Product 1

HCID 73058327HCID 73058327, compound

Procedure

The compound was prepared by using procedures analogous to those described for the synthesis of Example 53, Step 2 starting from 6-bromo-2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3-b]pyrazine and 2-(4-methylpiperazin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile. LCMS calculated for C28H31N6O2(M+H)+: m/z=483.2. Found 483.3.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-dbf81feae34d40a582d8006eb30244d6
Source dataset
uspto-grants-2016_07
Patent number
US09388185B2

Reaction notes

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