Sodium borohydride → HCID 86710980, compound

HRID 1052298Notes

Reaction equation

HRID 1052298 reaction equation
[BH4-].[Na+].[CH3:3][C:4]1([CH3:24])[C:8]([CH3:10])([CH3:9])[O:7][B:6]([C:11]2[CH:16]=[CH:15][C:14]([N:17]3[CH2:22][CH2:21][C:20](=[O:23])[CH2:19][CH2:18]3)=[CH:13][CH:12]=2)[O:5]1>CO>[CH3:9][C:8]1([CH3:10])[C:4]([CH3:3])([CH3:24])[O:5][B:6]([C:11]2[CH:12]=[CH:13][C:14]([N:17]3[CH2:22][CH2:21][CH:20]([OH:23])[CH2:19][CH2:18]3)=[CH:15][CH:16]=2)[O:7]1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 86710933HCID 86710933, compound

Product 1

HCID 86710980HCID 86710980, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

Sodium tetrahydroborate (0.012 g, 0.33 mmol) was added to a mixture of 1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperidin-4-one (0.050 g, 0.17 mmol, from Combi-Blocks) in methanol (1.0 mL) at 0° C. and then the reaction was stirred at 0° C. for 1 hour. The solvent was removed and the residue was treated with water and then filtered. The residue was dried to provide the desired product as a white solid. LCMS calculated for C17H27BNO3 (M+H)+: m/z=304.2. Found 304.1.

Workup

  1. customThe solvent was removed
  2. additionthe residue was treated with water
  3. filtrationfiltered
  4. customThe residue was dried

Sources & evidence

ORD record
ord-d2ac2216ad7a410c901843b0a2c3249a
Source dataset
uspto-grants-2016_07
Patent number
US09388185B2

Reaction notes

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