Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Selectfluor | HCID 2724933 | — |
| Reactant | 6-bromo-2-[2-(3,5-dimethoxyphenyl)ethyl]-5-(phenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazine | HCID 89963723 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 89963598 | HCID 89963598 | — |
Reaction Steps
A mixture of 6-bromo-2-[2-(3,5-dimethoxyphenyl)ethyl]-5-(phenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazine (25.0 mg, 0.0498 mmol) and 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane ditetrafluoroborate (17.6 mg, 0.0498 mmol) in acetonitrile (0.3 mL)/water (0.06 mL) was stirred at 50° C. overnight. The solvent was removed and the residue was used in the next step w/o purification. LCMS calculated for C22H20BrFN3O4S (M+H)+: m/z=520.0. Found 520.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09388185B2 |
|---|
| Source dataset | uspto-grants-2016_07 |
|---|
| ORD ID | ord-34df7497b2b94df1a36b35939ea8ee25 |
|---|
| Source note | uspto-grants-2016_07 |
|---|
