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HRID1052424

反应详情

EQUATION

反应方程式

HRID 1052424 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：COc1cccc(S)c1
HCID84989

Benzenethiol, 3-methoxy-

C7H8OS

结构：C[C@H](NC(=O)OC(C)(C)C)c1nn2ccc(I)c2c(=O)n1-c1ccccc1
HCID131736123

未命名化合物

PRODUCTS

生成物

1
结构：COc1cccc(Sc2ccn3nc([C@H](C)NC(=O)OC(C)(C)C)n(-c4ccccc4)c(=O)c23)c1
HCID131736152

未命名化合物

收率 30%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：[Cu][I]
催化剂HCID24350

Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

CuI

PROCEDURE

实验过程

(S)-tert-Butyl (1-(5-iodo-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)carbamate (500 mg, 1.04 mmol) was treated with 3-methoxybenzenethiol (219 mg, 1.56 mmol), potassium carbonate (216 mg, 1.56 mmol) and copper(I) iodide (297 mg, 1.56 mmol) according to the method described in Preparation 44. The residue was purified by reverse phase using Isolera® Purification System to give 154 mg (30% yield) to the title compound. Purity 100%.

WORKUP

后处理

  1. customdescribed in Preparation 44
  2. customThe residue was purified by reverse phase
  3. customIsolera® Purification System