反应详情

温度

0 °C

4,6-Dichloro-N-(3-fluoro-5-methoxyphenyl)pyrimidine-5-carboxamide (800 mg, 1.42 mmol) was dissolved in dioxane (5 ml) and cooled in an ice bath. Ammonia solution (1 ml, 7N in MeOH) was added dropwise and the mixture was stirred at 0° C. for 6 h and overnight at room temperature. After evaporation of the solvent under reduced pressure, the residue (458 mg, 100%) was used in the next synthetic step without further purification.

1. temperaturecooled in an ice bath
2. customAfter evaporation of the solvent under reduced pressure
3. customthe residue (458 mg, 100%) was used in the next synthetic step without further purification