Ammonium Chloride → HCID 90103494, compound

Participants

Reaction Steps

2-(3-(Dimethylamino)propoxy)-5-nitrophenol (220 mg 0.92 mmol), ammonium chloride (232 mg, 4.34 mmol) and powdered iron (242 mg, 4.33 mmol) were suspended in THF (5 ml) and water (10 ml) and the mixture was stirred at 70° C. overnight. The reaction mixture was diluted with water, neutralised to pH=6 with sodium carbonate and extracted with ethyl acetate (×3). The organic phase was washed successively with water and brine, dried over magnesium sulphate, filtered and the solvent evaporated under reduced pressure. 75 mg (24% yield, 61% purity) of the title compound were obtained and used in the next synthetic step without further purification.

Provenance & Evidence