4-Methoxybenzenesulfonyl chloride → HCID 90103047, compound

HRID 1052468Notes

Reaction equation

HRID 1052468 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[C:6]([Br:8])[CH:7]=1.[CH3:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([S:18](Cl)(=[O:20])=[O:19])=[CH:14][CH:13]=1>>[Br:8][C:6]1[CH:7]=[C:2]([NH:1][S:18]([C:15]2[CH:14]=[CH:13][C:12]([O:11][CH3:10])=[CH:17][CH:16]=2)(=[O:20])=[O:19])[CH:3]=[C:4]([OH:9])[CH:5]=1

Participants

3

Reactant 2

HCID 74014-Methoxybenzenesulfonyl chlorideHCID 183882723-Amino-5-bromophenol

Product 1

HCID 90103047HCID 90103047, compoundYield 86.8%

Procedure

3-Amino-5-bromophenol (0.75 g, 3.99 mmol, prepared according to WO 2011119704 A1 20110929) was treated with 4-methoxybenzene-1-sulfonyl chloride (1.61 g, 7.79 mmol) according to the method described In Preparation 15b to give 1.24 g (77% yield) of the title compound as an oil. Purity 89%.

Sources & evidence

ORD record
ord-4c12963e94ee45a2b841059102fa1642
Source dataset
uspto-grants-2016_07
Patent number
US09388189B2

Reaction notes

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