Boron tribromide → N-(5-Bromo-2-chloropyridin-3-yl)-4-hydroxybenzenesulfonamide

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Reaction Steps

N-(5-Bromo-2-chloropyridin-3-yl)-4-methoxybenzenesulfonamide (1.49 g, 3.95 mmol) was treated with boron tribromide (1M in dichloromethane, 20 ml, 20 mmol) with dichloromethane (10 ml) as a solvent according to the method described in Example 23. The resulting crude was purified by flash chromatography using SP1® Purification System (0% to 30%, dichloromethane-ethyl acetate) to obtain 0.6 g (42% yield) of the title compound. Purity: 100%

Provenance & Evidence