4-Fluorobenzenesulfonyl chloride → HCID 90102830, compound

HRID 1052478Notes

Reaction equation

HRID 1052478 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[C:6]([Br:8])[CH:7]=1.[F:10][C:11]1[CH:16]=[CH:15][C:14]([S:17](Cl)(=[O:19])=[O:18])=[CH:13][CH:12]=1>>[Br:8][C:6]1[CH:7]=[C:2]([NH:1][S:17]([C:14]2[CH:15]=[CH:16][C:11]([F:10])=[CH:12][CH:13]=2)(=[O:19])=[O:18])[CH:3]=[C:4]([OH:9])[CH:5]=1

Participants

3

Reactant 2

HCID 95884-Fluorobenzenesulfonyl chlorideHCID 183882723-Amino-5-bromophenol

Product 1

HCID 90102830HCID 90102830, compoundYield 104.6%

Procedure

3-Amino-5-bromophenol (300 mg, 1.4 mmol, prepared according to WO 2011119704 A1 20110929) was treated with 4-fluorobenzene-1-sulfonyl chloride (326 mg, 1.68 mmol) according to the method described in Preparation 15b to give 507 mg (99% yield) of the title compound as an oil. Purity 70%.

Sources & evidence

ORD record
ord-8bcfcd91803e4335ae68f33753970ffa
Source dataset
uspto-grants-2016_07
Patent number
US09388189B2

Reaction notes

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