4-Methoxybenzenesulfonyl chloride → HCID 90102289, compound

HRID 1052479Notes

Reaction equation

HRID 1052479 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([F:9])[CH:8]=1)[NH2:5].[CH3:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([S:18](Cl)(=[O:20])=[O:19])=[CH:14][CH:13]=1>>[Br:1][C:2]1[CH:3]=[C:4]([NH:5][S:18]([C:15]2[CH:14]=[CH:13][C:12]([O:11][CH3:10])=[CH:17][CH:16]=2)(=[O:20])=[O:19])[CH:6]=[C:7]([F:9])[CH:8]=1

Participants

3

Reactant 2

HCID 74014-Methoxybenzenesulfonyl chlorideHCID 150201553-Bromo-5-fluoroaniline

Product 1

HCID 90102289HCID 90102289, compoundYield 88%

Procedure

3-Bromo-5-fluoroaniline (500 mg, 2.63 mmol) was treated with 4-methoxybenzene-1-sulfonyl chloride (572 mg, 2.77 mmol) according to the method described in Preparation 15b to give 832 mg (88% yield) of the title compound as an oil. Purity 70%.

Sources & evidence

ORD record
ord-ed63f3b489984e1eb00961d11cc3cc89
Source dataset
uspto-grants-2016_07
Patent number
US09388189B2

Reaction notes

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