4-Methoxybenzenesulfonyl chloride → HCID 90102616, compound

HRID 1052491Notes

Reaction equation

HRID 1052491 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH2:10])[C:5]([CH2:8][CH3:9])=[N:6][CH:7]=1.[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([S:19](Cl)(=[O:21])=[O:20])=[CH:15][CH:14]=1>>[Br:1][C:2]1[CH:3]=[C:4]([NH:10][S:19]([C:16]2[CH:15]=[CH:14][C:13]([O:12][CH3:11])=[CH:18][CH:17]=2)(=[O:21])=[O:20])[C:5]([CH2:8][CH3:9])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 74014-Methoxybenzenesulfonyl chlorideHCID 57545913HCID 57545913, compound

Product 1

HCID 90102616HCID 90102616, compoundYield 87.4%

Procedure

5-Bromo-2-ethyl-3-pyridinamine (285 mg, 1.42 mmol, prepared according to WO 2008157191 A2 20081224) was treated with 4-methoxybenzene-1-sulfonyl chloride (323 mg, 1.56 mmol) according to the method described In Preparation 15b to give 461 mg (75% yield) of the title compound as an oil. Purity 85%.

Sources & evidence

ORD record
ord-e113dcf0315541f48089bc9022c323d1
Source dataset
uspto-grants-2016_07
Patent number
US09388189B2

Reaction notes

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