Ethyl Acetate → HCID 131736175, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of benzyl (2-((3-bromo-2-(phenylcarbamoyl)-1H-pyrrol-1-yl)amino)-2-oxoethyl)carbamate (7.81 g, purity 45%, 7.48 mmol) in toluene (80 ml) in a reactor equipped with a Dean-Stark destilator was added pyridinium p-toluene sulfonate (1.88 g, 7.48 g) and the reaction mixture was stirred at 120° C. for 3 days. The crude was diluted with ethyl acetate and washed with water and brine, dried over magnesium sulphate and the solvent was removed to give 7.39 g (100% yield) of the final product as a dark oil. Estimated purity 46%. This crude was used in the next step without further purification.

Provenance & Evidence