4-Methoxybenzenesulfonyl chloride → HCID 90102972, compound

HRID 1052513Notes

Reaction equation

HRID 1052513 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH2:11])[C:5]([NH:8][CH2:9][CH3:10])=[N:6][CH:7]=1.[CH3:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[CH:16][CH:15]=1>>[Br:1][C:2]1[CH:3]=[C:4]([NH:11][S:20]([C:17]2[CH:16]=[CH:15][C:14]([O:13][CH3:12])=[CH:19][CH:18]=2)(=[O:22])=[O:21])[C:5]([NH:8][CH2:9][CH3:10])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 74014-Methoxybenzenesulfonyl chlorideHCID 61229238HCID 61229238, compound

Product 1

HCID 90102972HCID 90102972, compoundYield 35%

Procedure

5-Bromo-N2-ethylpyridine-2,3-diamine (290 mg, 1.34 mmol, purchased from Aurora Building Blocks reference A01.414.067) was treated with 4-methoxybenzene-1-sulfonyl chloride (280 mg, 1.35 mmol) according to the method described in Preparation 15b to give 180 mg (35% yield) of the title compound as an oil. Purity 99%.

Sources & evidence

ORD record
ord-663772d0fca54cbca4f793e5713a9949
Source dataset
uspto-grants-2016_07
Patent number
US09388189B2

Reaction notes

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