Sodium Carbonate → HCID 131736179, compound

Participants

Reaction Steps

(S)-2-(1-((5-Bromo-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (93 mg, 0.16 mmol) was treated with 2-(3-fluoro-5-methoxybenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (130 mg, 0.38 mmol), sodium carbonate (40 mg, 0.38 mmols) and 1,1′-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex (11 mg, 0.02 mmol) in a mixture of 1,2-dimethoxyethane (1.1 ml) and water (0.3 ml) according to the method described in Preparation 62. The residue was purified using SP1® Purification System (0% to 40%, hexane-ethyl acetate) to give 14 mg (9% yield, 68% purity) of the title compound.

Provenance & Evidence