4-Methoxybenzenesulfonyl chloride → HCID 118433936, compound

HRID 1052530Notes

Reaction equation

HRID 1052530 reaction equation
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][NH:8]2)=[CH:4][CH:3]=1.[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([S:19](Cl)(=[O:21])=[O:20])=[CH:15][CH:14]=1>>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][N:8]2[S:19]([C:16]2[CH:15]=[CH:14][C:13]([O:12][CH3:11])=[CH:18][CH:17]=2)(=[O:21])=[O:20])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 74014-Methoxybenzenesulfonyl chlorideHCID 178424716-Bromo-1H-indazole

Product 1

HCID 118433936HCID 118433936, compoundYield 87.9%

Procedure

6-Bromo-1H-indazole (500 mg, 2.54 mmol) was treated with 4-methoxybenzene-1-sulfonyl chloride (576 mg, 2.79 mmol) according to the method described in Preparation 15b to give 820 mg (81% yield) of the title compound. Purity 92%.

Sources & evidence

ORD record
ord-952593db26c4400b81b43c652b55dcbc
Source dataset
uspto-grants-2016_07
Patent number
US09388189B2

Reaction notes

Loading…