4-Methoxybenzenesulfonyl chloride → HCID 67102887, compound

HRID 1052532Notes

Reaction equation

HRID 1052532 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH2:11])[C:5]2[CH:6]=[CH:7][NH:8][C:9]=2[CH:10]=1.[CH3:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[CH:16][CH:15]=1>>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[C:4]([NH:11][S:20]([C:17]2[CH:16]=[CH:15][C:14]([O:13][CH3:12])=[CH:19][CH:18]=2)(=[O:22])=[O:21])[CH:3]=1

Participants

3

Reactant 2

HCID 74014-Methoxybenzenesulfonyl chlorideHCID 105126634-Amino-6-bromoindole

Product 1

HCID 67102887HCID 67102887, compoundYield 118.5%

Procedure

6-Bromo-1H-indol-4-amine (500 mg, 1.97 mmol) was treated with 4-methoxybenzene-1-sulfonyl chloride (446 mg, 2.16 mmol) according to the method described in Preparation 15b to give 890 mg (100% yield) of the title compound. Purity 87%.

Sources & evidence

ORD record
ord-ac29154fd7fc4688a0f4fecab7e7fbc0
Source dataset
uspto-grants-2016_07
Patent number
US09388189B2

Reaction notes

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