4-Methoxybenzenesulfonyl chloride → HCID 131736190, compound

HRID 1052535Notes

Reaction equation

HRID 1052535 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:19])[C:5]2[CH:6]=[CH:7][N:8]([CH2:11][O:12][CH2:13][CH2:14][Si:15]([CH3:18])([CH3:17])[CH3:16])[C:9]=2[CH:10]=1.[CH3:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([S:28](Cl)(=[O:30])=[O:29])=[CH:24][CH:23]=1>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][N:8]2[CH2:11][O:12][CH2:13][CH2:14][Si:15]([CH3:16])([CH3:18])[CH3:17])=[C:4]([NH:19][S:28]([C:25]2[CH:24]=[CH:23][C:22]([O:21][CH3:20])=[CH:27][CH:26]=2)(=[O:30])=[O:29])[CH:3]=1

Participants

3

Reactant 2

HCID 74014-Methoxybenzenesulfonyl chlorideHCID 90102981HCID 90102981, compound

Product 1

HCID 131736190HCID 131736190, compoundYield 97%

Procedure

6-Chloro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indol-4-amine (880 mg, 2.52 mmol) was treated with 4-methoxybenzene-1-sulfonyl chloride (572 mg, 2.77 mmol) according to the method described in Preparation 15b to give 1.48 mg (97% yield) of the title compound. Purity 85%.

Sources & evidence

ORD record
ord-b207d742149048f5b16518cc0bb72199
Source dataset
uspto-grants-2016_07
Patent number
US09388189B2

Reaction notes

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