Methanesulfonyl chloride → HCID 3693343, compound

HRID 1052543Notes

Reaction equation

HRID 1052543 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:7]=[C:8]([O:10][CH3:11])[CH:9]=1)[NH2:6].[CH3:12][S:13](Cl)(=[O:15])=[O:14]>N1C=CC=CC=1>[CH3:11][O:10][C:8]1[CH:7]=[C:5]([NH:6][S:13]([CH3:12])(=[O:15])=[O:14])[CH:4]=[C:3]([O:2][CH3:1])[CH:9]=1

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chloride2×HCID 663013,5-Dimethoxyaniline

Product 1

HCID 3693343HCID 3693343, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3,5-Dimethoxyaniline (1 g mg, 6.53 mmol) was dissolved in pyridine (48 ml) and was treated with methanesulfonyl chloride (0.56 ml, 7.18 mmol). The reaction mixture was stirred at room temperature overnight. Methanesulfonyl chloride (0.28 ml, 3.59 mmol) was added and the mixture was stirred at room temperature overnight. The solvent was removed to give 1.7 mg (100% yield) of the title compound as a dark oil. Purity 89%.

Workup

  1. stirringthe mixture was stirred at room temperature overnight
  2. customThe solvent was removed

Sources & evidence

ORD record
ord-b94e377fd2f049a8884586d672118fad
Source dataset
uspto-grants-2016_07
Patent number
US09388189B2

Reaction notes

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