Methylamine → 4-Methoxy-N-methylbenzenesulfonamide

HRID 1052552Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1052552
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9](Cl)(=[O:11])=[O:10])=[CH:5][CH:4]=1.[CH3:13][NH2:14]>ClCCl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([NH:14][CH3:13])(=[O:11])=[O:10])=[CH:5][CH:4]=1

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 74014-Methoxybenzenesulfonyl chloride

Produkt 1

HCID 24974294-Methoxy-N-methylbenzenesulfonamideAusbeute 104,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

4-Methoxybenzene-1-sulfonyl chloride (1 g, 4.84 mmol) was dissolved in dichloromethane (15 mL) and was treated with methanamine (9.7 ml, 19.40 mmol). The reaction mixture was stirred at room temperature for two hours. The crude was filtered and washed with dichloromethane to give 1.02 g (100% yield) of the title compound as a white solid. Purity 95%.

Aufarbeitung

  1. filtrationThe crude was filtered
  2. washwashed with dichloromethane

Quellen und Nachweise

ORD-Eintrag
ord-a2b0c4a9b5f9474b9f2eebe261666572
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09388189B2

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