Methanesulfonyl chloride → HCID 67102634, compound

HRID 1052558Notes

Reaction equation

HRID 1052558 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH2:11])[C:5]2[CH:6]=[CH:7][NH:8][C:9]=2[CH:10]=1.[CH3:12][S:13](Cl)(=[O:15])=[O:14]>>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[C:4]([NH:11][S:13]([CH3:12])(=[O:15])=[O:14])[CH:3]=1

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 105126634-Amino-6-bromoindole

Product 1

HCID 67102634HCID 67102634, compoundYield 101.8%

Procedure

6-Bromo-1H-indol-4-amine (500 mg, 1.97 mmol) was treated with methanesulfonyl chloride (167 μl, 2.16 mmol) according to the method described in Preparation 15b to give 580 mg (91% yield) of the title compound. Purity 89%.

Sources & evidence

ORD record
ord-c96a9a359d2e429e84c334b34cd6eb58
Source dataset
uspto-grants-2016_07
Patent number
US09388189B2

Reaction notes

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