反应详情

(S)-2-(1-((5-Bromo-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (53 mg, 0.09 mmol) was treated with N-(3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-2-methoxyethanesulfonamide (80 mg, 0.22 mmol), sodium carbonate (24 mg, 0.22 mmol) and 1,1′-Bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex (22 mg, 0.03 mmol) in 1,2-dimethoxyethane (2 ml) and water (0.5 ml) according to the method described in Preparation 62. The residue was purified using SP1® Purification System (0% to 70% n-hexane-ethyl acetate) to obtain 59 mg (69% yield, 78% purity) of the title compound.

1. customdescribed in Preparation 62
2. customThe residue was purified
3. customSP1® Purification System (0% to 70% n-hexane-ethyl acetate)