Methanesulfonyl chloride → N-(3-Bromo-5-(trifluoromethyl)phenyl)methanesulfonamide

HRID 1052573Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1)[NH2:5].[CH3:13][S:14](Cl)(=[O:16])=[O:15]>>[Br:1][C:2]1[CH:3]=[C:4]([NH:5][S:14]([CH3:13])(=[O:16])=[O:15])[CH:6]=[C:7]([C:9]([F:10])([F:11])[F:12])[CH:8]=1

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 27358803-Bromo-5-(trifluoromethyl)aniline

Product 1

HCID 65491442N-(3-Bromo-5-(trifluoromethyl)phenyl)methanesulfonamideYield 101.8%

Procedure

3-Bromo-5-(trifluoromethyl)aniline (1 g, 4.17 mmol) was treated with methanesulfonyl chloride (480 μl, 6.25 mmol) according to the method described in Preparation 15b to give 1.35 g (97% yield) of the title compound. Purity 96%.

Sources & evidence

ORD record: ord-43d13f067f414e38b40c5c0968fae438
Source dataset: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09388189B2

Reaction notes

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