Ammonia → 2-[(1S)-1-[[5-(2-hydroxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]ethyl]-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4-one

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Reaction Steps

(S)-2-(1-((5-(2-Hydroxyphenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (52 mg, 0.09 mmol) was treated with trifluoroacetic acid (1.04 mL, 13.50 mmol) and a solution of ammonia (7N in methanol, 1.04 mL, 7.28 mmol) according to the method described in Example 27 to give 23 mg (56% yield) of the title compound. Purity 98%.

Provenance & Evidence