Ammonia → 2-[(1S)-1-[[5-(4-hydroxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]ethyl]-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4-one

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Reaction Steps

(S)-2-(1-((5-(4-Hydroxyphenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (48 mg, 0.08 mmol) was treated with trifluoroacetic acid (960 μl, 12.46 mmol) and a solution of ammonia (7N in methanol, 960 μl, 6.72 mmol) according to the method described in Example 27 to give 26 mg (69% yield) of the title compound. Purity 95%.

Provenance & Evidence