反应详情

(S)-4-Amino-N-(3-methoxyphenyl)-6-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)pyrimidine-5-carboxamide (27 mg, 0.05 mmol) was treated with boron tribromide (1M in dichloromethane, 160 μl, 0.16 mmol) in dichloromethane according to the method described in Example 23. The residue was purified by reverse phase using SP1® Purification System to give 6 mg (23% yield) as a white solid. Purity 100%.

1. customThe residue was purified by reverse phase
2. custom® Purification System
3. customto give 6 mg (23% yield) as a white solid