Cesium fluoride → (S)-Benzyl 4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate

Participants

Reaction Steps

(S)-2-(1-Aminoethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (56 mg, 0.21 mmol) was treated with benzyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate (70 mg, 0.24 mmol), cesium fluoride (14 mg, 0.09 mmol), N,N-diisopropylethylamine (163 μl, 0.94 mol) according to Preparation 13 to give 27 mg (25% yield) of the title compound as a white solid.

Provenance & Evidence